Below you will find a list of the trials and studies being run by members of Pancreatic Cancer Research Programme at the Centre.



Tissue/blood collection

PORTICO-Trans: A feasibility study looking at the immune system in tumours, comparing samples collected during surgery to those taken afterwards

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Locally advanced

GRECO-2: A Randomised, Phase 2 Study of Stereotactic Body Radiation Therapy (SBRT) in combination with GC4711 in the Treatment of Unresectable or Borderline Resectable, Nonmetastatic Pancreatic Cancer

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Operable PDAC

Portico-SABR: Investigate the effects and safety of SABR treatment given to patients with operable pancreatic cancer prior to surgery to remove the tumour

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Metastatic - 1st or 2nd line

daNIS-2: A randomised, double-blind, phase III study comparing NIS793 in combination with gemcitabine and nab-paclitaxel versus placebo combined with gemcitabine and nab-paclitaxel for first line treatment of metastatic pancreatic ductal adenocarcinoma (mPDAC)

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Metastatic - 2nd line and beyond

Porcupine 2: A Modular, Phase II, Open-Label, Multicentre Study to Assess the Preliminary Efficacy and Safety of RXC004, in Patients with Advanced Solid Tumours that have Progressed following Therapy with Current Standard of Care who have the RNF43 rearrangement.

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