Research |

 Trials

 

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The following trials are currently in development or open for recruitment at Addenbrooke’s hospital in Cambridge:

Trial Name Treatment Outline Comments
ESPAC-4 Gemcitabine
Capecitabine
Comparison of gemcitabine-capecitabine chemotherapy combination to gemcitabine alone in patients who have undergone surgery for the removal of pancreatic cancer. UKCRN ID 4307. Multi-centre trial. Now open to ampullary patients only.
PRICKLE Gemcitabine
Nab-Paclitaxel
Combination Gemcitabine/Nab-Paclitaxel in borderline locally advanced pancreatic cancer. Initiated in Cambridge. UKCRN ID 16739. Open to recruitment.
CAM-PLEX AMD3100 (Plerixafor) Assessment of the safety of Plerixafor in patients with advanced pancreatic, high grade serous ovarian and colorectal adenocarcinomas. Initiated in Cambridge. UKCRN ID 19088.
Open to recruitment.
STAR-PAC Gemcitabine
Nab-Paclitaxel
ATRA
Assessment of ATRA in combination with gemcitabine and Nab-Paclitaxel in patients with locally advanced or metastatic pancreatic cancer. Multi-centre trial. Open to recruitment.
Scalop 2 Capecitabine
Nelfinavir
Radiotherapy
Induction chemotherapy followed by capecitabine +/- nelfinavir, with high or standard dose radiotherapy in locally-advanced, non-metastatic pancreatic cancer. Multi-centre trial. Open to recruitment.
SIEGE Gemcitabine
Nab-Paclitaxel
Comparison of different schedules of the combination of Gemcitabine/Nab-Paclitaxel in patients with metastatic pancreatic cancer. Multi-centre trial. Initiated in Cambridge. UKCRN ID 15344.
Closed to recruitment.
APACT Gemcitabine
Nab-Paclitaxel
Comparison of Gemcitabine/Nab-Paclitaxel combination to Gemcitabine alone as adjuvant therapy for patients who have undergone surgery for the removal of pancreatic cancer. Multi-centre international trial. Closed to recruitment.

 

  • These trials cover different stages of disease, and will therefore be relevant for different groups of patients. The trials that were conceived and designed in Cambridge have been indicated.
  • We are constantly following new leads on potential therapies, and have a number of other trials that are currently under development. This page will be updated when these studies open.
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    The following websites have publicly accessible databases of clinical trials:
    http://www.clinicaltrials.gov/
    http://www.cancerresearchuk.org/cancer-help/